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Hematopathology

The division of hematopathology includes routine and special hematology, bone marrow lab, flow cytometry, hemostatsis and thrombosis and urinalysis. See the home page test menu for specific specimen collection information.

Service

Personalized Communication

  • The hematopathologist contacts the physician when the biopsy findings require discussion. A faxed final report will follow.
  • The pathology outreach coordinator and hematopathology office staff make regular contact with your office to ensure quality of service.

Meet the Hematopathology team of physicians

  • Liang Cheng, MD, PhD

    PROFESSOR

    Education: MD Beijing Medical University, China, PhD Karolinska Institute Stockholm, Sweden, Resident in Pathology, Case Western Reserve University, Fellow in Urologic Surgical Pathology, Mayo Clinic
    Board Certification: Diplomate of the American Board of Pathology in Anatomic and Clinical Pathology
    Subspecialty Certification: Molecular Genetic Pathology
    Special Interest: Urologic pathology,Molecular diagnostics, and Molecular genetic pathology
    Address: Indiana University Health Pathology Laboratory
    350 W. 11th St., Room 4044
    Indianapolis, IN 46202-4108
    Phone: 317.491.6442
    Fax: 317.491.6419
    Pager: 312.4821
    E-mail: lcheng@iupui.edu

  • Magdalena Czader, MD, PhD

    ASSOCIATE PROFESSOR; DIRECTOR, HEMATOPATHOLOGY; DIRECTOR, HEMATOPATHOLOGY FELLOWSHIP PROGRAM

    Education: MD Karol Marcinkowski University of Medical Sciences, Poland; PhD Karolinska Institute Stockholm, Sweden
    Resident in Pathology, Johns Hopkins Medical Institutions; Fellow in Hematopathology, Johns Hopkins Medical Institutions
    Board Certification: Diplomate of the American Board of Pathology in Anatomic and Clinical Pathology
    Subspecialty Certification: Hematopathology
    Special Interest: Hematopathology and Flow Cytometry, Adult and Pediatric Leukemias and Lymphomas
    Address: Indiana University Health Pathology Laboratory
    350 W. 11th St., Room 5034
    Indianapolis, IN 46202-4108
    Phone: 317.491.6564
    Fax: 317.491.6114
    Pager: 312.1565
    E-mail: mczader@iupui.edu

  • Mehdi Nassiri, MD

    ASSISTANT PROFESSOR

    Education: MD University of Tehran, Iran; Resident in Pathology, University of Miami, Jackson Memorial Hospital; Fellow in Hematopathology, University of Miami, Jackson Memorial Hospital; Fellow in Molecular Pathology and Informatics, University of Miami School of Medicine
    Board Certification: Diplomate of the American Board of Pathology in Anatomic and Clinical Pathology
    Subspecialty Certification: Hematology
    Special Interest: Molecular Pathology, Medical Informatics, Biomarker discovery by high throughput methods
    Address: Indiana University Health Pathology Laboratory
    350 West 11th St., Room 5044
    Indianapolis, IN 46202-4108
    Phone: 317.491.6599
    Fax: 317.491.6419
    Pager: 312.6944
    E-mail: mnassiri@iupui.edu

  • Boguslaw I. Uchman, MD

    CLINICAL ASSISTANT PROFESSOR; MEDICAL DIRECTOR OF THROMBOSIS AND HEMOSTASIS LABORATORY

    Education: MD Academy of Medicine, Poland; Resident in Pathology in Anatomic and Clinical Pathology, Ball Memorial Hospital;
    Research Fellow: Ball Memorial Hospital, Muncie, Indiana; Fellowship in Hematopathology, Indiana University Hospital
    Board Certification: Diplomate of the American Board of Pathology in Anatomic Pathology and Clinical Pathology
    Special Interest: Hematopathology, Coagulation
    Address: Indiana University Health Pathology Laboratory
    350 West 11th St., Room 5038
    Indianapolis, IN 46202-4108
    Phone: 317.491.6561
    Fax: 317.491.6114
    Cell: 317.506.4129
    E-mail: buchman@iuhealth.org

  • Shanxiang Zhang, MD, PhD

    ASSISTANT PROFESSOR

    Education: MD Shanghai Medical University, China; PhD in Human Cancer Genetics, The Ohio State University; Resident in Pathology, SUNY Downstate Medical Center; Resident in Internal Medicine, First Hospital of Nanjing Medical University, China; Fellow in Hematopathology, Albert Einstein College of Medicine; Fellow in Oncologic Surgical Pathology at Roswell Park Cancer Institute
    Board Certification: Diplomate of the American Board of Pathology in Anatomic and Clinical Pathology
    Special Interest: Hematopathology  
    Address: Indiana University Health Pathology Laboratory
    350 West 11th St., Room 5042
    Indianapolis, IN 46202-4108
    Phone: 317.491.6175
    Fax: 317.491.6114
    Pager: 312.5032
    E-mail:  sz5@iupui.edu

  • Jiehae Zhou, MD, PhD

    ASSISTANT PROFESSOR

    Education: MD Beijing Medical University, China;  PhD in Pathology from the University of Southern California; Resident in Pathology, University of Buffalo; Fellow in Hematopathology, Indiana University School of Medicine 
    Board Certification: Diplomate of the American Board of Pathology in Anatomic and Clinical Pathology
    Special Interest: Hematopathology  and flow cytometry analysis
    Address: Indiana University Health Pathology Laboratory
    350 West 11th St., Room 5036
    Indianapolis, IN 46202-4108
    Phone: 317.491.6563
    Fax: 317.491.6114
    Pager: 312.5335
    E-mail:  zhouji@iupui.edu

Expertise

10-Color Flow Cytometry

  • Leukemia and lymphoma profiles
  • T- and B-cell subsets (CD4 )
  • Customized clinical/research protocols
  • Flow cytometry requisition form

Hemostasis and Thrombosis

  • Extensive in-house test menu
  • Special panels
  • Experienced, dedicated technical staff and pathology consultation
  • Hemostasis and thrombosis requisition form
  • Hemostasis and thrombosis collection chart

Immunohistochemistry

  • Extensive panels of B- and T-cell markers
  • Prognostic and diagnostic markers
  • Numerous antibodies for evaluation of bone marrow and infection-associated hematologic diseases
  • Immunohistochemistry Ab requisition form

Molecular Diagnostics

  • Immunoglobulin heavy chain (IgH) gene rearrangement
  • T-cell gamma receptor gene rearrangement
  • BCL 2 and BCL1 translocation assays
  • Paraffin-embedded tissue testing
  • CLL and AML NGS Panels on larger resection specimens
  • Molecular Hematopathology requisition

Specimen Preparation & Transportation for Leukemia/Lymphoma Immunophenotyping

Bone Marrow Aspirate

Peripheral Blood

  • Send at least 5 mL in heparinized tube (use sodium heparin) at room temperature.
  • Also send a Wright's stained peripheral blood smear and CBC/diff results procured within 24 hours of collection of this sample.

Lymph Node or Other Solid Tissues

  • If possible, send at least 5x5x5 mm of tissue in RPMI 1640 medium (this can be requested from our laboratory).
  • Please keep the specimen at 2 to 8 degrees Celsius (wet ice) during transport (ice packs are sufficient).

Body Fluids

  • Please keep transport time to a minimum for cerebrospinal fluids. At least 4,000 cells should be submitted. (Use the following formula for calculation: cell count/ul x total volume [in mL] x 1000 = number of cells available.)
  • Transport on wet ice (2 to 8 degrees Celsius) is preferable.

Fine Needle Aspirates/Cores

  • If core biopsies are used, please submit at least two cores. For both fine needle aspirates and core biopsies, use RPMI 1640 medium and keep the specimen in 2 to 8 degrees Celsius during transport (ice packs are sufficient).

Specimens for T- and B-Cell Subsets, Paroxysmal Nocturnal Hemoglobinuria and Immunodeficiency Work-Up (Peripheral Blood Only)

  • Submit 5 mL of peripheral blood in sodium heparin. Include CBC/diff results performed within 24 hours of collection of flow cytometry sample.
  • Deliver specimen to the flow cytometry laboratory within 48 hours.

What to Do

  • Call the flow cytometry laboratory at 317.491.6000 before sending.
  • Include a completed requisition form.
  • Send specimens by courier or overnight delivery. If sending on Friday, please specify Saturday delivery.