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Neuropathology

Expertise

  • Neuroncology
  • Disorders of the muscle and peripheral nerve
  • Neurodegenerative disorders -- Federally funded Alzheimer Disease Center

Meet the Neuropathology team of physicians

  • Biagio Azzarelli, MD

    PROFESSOR EMERITUS

    Education: MD University of Chile School of Medicine; Resident in Pathology, Case Western Reserve University; Fellow in Neuropathology, Case Western Reserve University
    Board Certification: Diplomate of the American Board of Pathology in Neuropathology
    Special Interest: Central nervous system neoplasms, Muscle and nerve biopsy
    Address: Van Nuys Medical Science Building
    635 Barnhill Dr., Room A149
    Indianapolis, Indiana 46202-5120
    Phone: 317.274.4806
    E-mail: bazzarel@iupui.edu

  • José M. Bonnin, MD
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    CLINICAL PROFESSOR; DIRECTOR, NEUROPATHOLOGY FELLOWSHIP PROGRAM

    Education: MD National University of Asuncion, Paraguay; Resident in Pathology, Danbury Hospital; Fellow in Neuropathology, University of Virginia
    Board Certification: Diplomate of the American Board of Pathology in Anatomic and Clinical Pathology
    Subspecialty Certification: Neuropathology
    Special Interest: Neuropathology and Ophthalmic pathology
    Address: Indiana University Health Pathology Laboratory
    350 West 11th St., Room 4038
    Indianapolis, IN 46202-4108
    Phone: 317.491.6362
    Fax: 317.491.6172
    Pager: 312.7261
    E-mail: jbonnin@iupui.edu

  • Bernardino Ghetti, MD
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    DISTINGUISHED PROFESSOR, CHANCELLOR'S PROFESSOR

    Education: MD University of Pisa Medical School, Italy; Resident in Pathology, Albert Einstein College of Medicine; Fellow in Neuropathology, Albert Einstein College of Medicine
    Board Certification: Diplomate of the American Board of Pathology in Neuropathology
    Special Interest: Alzheimer's and other degenerative brain diseases
    Address: Van Nuys Medical Science Building
    635 Barnhill Dr., Room A128
    Indianapolis, Indiana 46202-5120
    Phone: 317.274.7818
    Fax: 317.274.4882
    Pager: 562.6474
    E-mail: ghetti@iupui.edu

  • Alexander Oliver Vortmeyer, MD, PhD
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    CLINICAL PROFESSOR

    Education:  M.D. University of Hamburg Medical School, Germany
    Ph.D. University of Hamburg Medical School, Germany
    Resident in Pathology, University of Hamburg, Germany, and  Laboratory of Pathology, National Cancer Institute;
    Fellow in Neuropathology, University of Hamburg, Germany, and Brigham and Women’s Hospital, Boston
    Subspecialty Certification: Neuropathology

    Special Interest: Neuropathology, Tumor suppressor gene syndromes

    Address:  IU Health Pathology Laboratory
    350 West 11th Street, Room 4034
    Indianapolis, IN 46202-4108
     

    Phone: 317-274 1618
    Fax: 317-491-6172
    Pager: 317-312-1558
    E-mail: avortmey@iu.edu

Expeditious Turn Around Time

  • Routine muscle biopsies: three to four days
  • Routine consults: 24 hours

Personalized Communication

  • A confirmation is faxed upon receipt of the specimen identifying the pathologist interpreting the case and providing contact numbers.
  • The pathologist contacts the physician when the biopsy findings require discussion. A faxed final report will follow.
  • The pathology outreach coordinator and neuropathology office staff make regular contact with your office to ensure quality of service.

Specimen Preparation and Transportation

  • Laboratory hours are Monday - Friday 7:30 am - 3 pm
  • Closed on weekends and holidays. Specimens are not accepted after-hours or on weekends. 
  • All specimens must arrive in our lab no later than 2 pm

Jump ahead on this page

Muscle Biopsy

Nerve Biopsy

Muscle Biopsy

Contact

  • Contacting Neuropathology prior to sending specimens ensures that laboratory staff are available to receive the fresh specimen.
  • Please call 317.491.6329 at least 24 hours in advance to provide patient information.
  • Contact the laboratory immediately when a biopsy has been canceled.
  • Call 317.491.6329 with technical questions about specimen collection.
  • To schedule a courier for specimen pick-up or for case inquiries, results, and reports, please contact Client Services at 1.800.433.0740 or 317.491.6000.
  • To register the patient with us, please complete the requisition form and fax it to 317-491-6419.
  • Send the requisition form and all accompanying information, including the most recent clinical information, with the biopsy.

Specimen Collection

  • Adhereing to the muscle biopsy collection directions below will prevent delay in processing your specimens.
  • Fresh sample required.
  • Muscle samples must be at least 20mm in length and 10mm in diameter.
  • One large piece of muscle is required (vastus lateralis, deltoid, or biceps). Submitting small fragments and poor samples will hinder proper processing/testing and a new sample may be requested.
  • Wrap muscle loosely in gauze that has been moistened with three drops of saline and place in plastic specimen cup with lid.  Oversaturating muscle with saline will compromise the integrity of the muscle, as well as testing.
  • Do not introduce the following materials to sampled muscle tissue:  
    • No thread or stitches or sutures
    • No clamps or tongue depressors
    • No pins or needles
    • No fixative
    • No cautery

Transportation

  • Whether sending by courier or overnight, fresh muscle biopsies should always be kept cool during transport.
  • Place sample in specimen cup, place in biohazard bag, and transport on ice packs. Never use dry ice.
  • Include completed requisition form with specimen and label exterior of package with: Indiana University Health Pathology Laboratory
    350 W. 11th Street
    Neuropathology Lab Room 4001
    Indianapolis, IN 46202-4108

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Nerve Biopsy

Contact

  • Complete the requisition form
  • Contacting Neuropathology prior to sending specimens is recommended. This ensures that laboratory staff are available to receive the specimen.
  • Please call 317.491.6329 at least 24 hours in advance to provide patient information.
  • Contact the laboratory immediately if a biopsy has been canceled.
  • For technical questions regarding specimen collection, call 317.491.6329.
  • To schedule a courier or for case inquiries, results and reports, contact Client Services at 1.800.433.0740 or 317.491.6000.

Specimen Collection (Collect using either method below)

Method 1: 10 Percent Formalin Fixed

  • Handle specimen gently and place in 10 percent neutral buffered formalin immediately.
  • DO NOT CUT NERVE INTO FRAGMENTS. One long piece of nerve is required.  Submitting small fragments and poor samples will hinder proper processing/testing and a new sample may be required.
  • Clamps, pins, sutures, stitches and tongue depressors should NOT be used for transporting nerve biopsies. These items damage and delicate tissue.

Method 2: Preserved in Glutaraldehyde (Recommended for overnight shipments)

  • Items needed: 3 percent glutaraldehyde, screw-top tube, index card.
  • Handle specimen gently.
  • DO NOT CUT NERVE INTO FRAGMENTS. Place fresh sural nerve on index card (cut to be slightly bigger than nerve but still able to fit in test tube) and let it adhere for 30 seconds.  
  • Fill test tube with 3 percent glutaraldehyde. Place the nerve with index card into the test tube and close tightly. The nerve should be completely submerged in glutaraldehyde. 
  • On test tube, write patient's name and time that the tissue was placed in glutaraldehyde.

Transportation

  • Once samples are collected and placed in fixative, they can be sent via courier.
  • Label the exterior of the package with the address listed below.
  • Include completed requisition form with specimen and label the exterior of the package:
    Indiana University Health Pathology Laboratory
    350 W. 11th Street
    Neuropathology Lab Room 4001
    Indianapolis, IN 46202-4108

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Websites

IUSM Department of Pathology and Laboratory Medicine

ARUP Consult - Physician Guide to Lab Test Selection and Interpretation

Mayo Medical Laboratories - Physician Clinical Resources

Lab Tests Online - A Public Resource on Clinical Lab Testing

Content Modified on: 3/23/2011 2:30:36 PM