Basic Science Research

Methodist Research Institute (MRI) enjoys a strong presence in the national and international scientific community because of the work done by its investigators. Six basic science laboratories focus on research to better understand the cause of diseases, to analyze the mechanisms behind current treatments and to explore potential new therapies. Basic science is the foundation for medical breakthroughs. MRI scientists are NIH funded and serve on numerous editorial boards and grant-review committees. Working with researchers at the Indiana University School of Medicine as well as international collaborators, the investigators of MRI have focused their efforts in several areas.


Anticancer activities of natural compounds, such as edible mushrooms, and how their biologically active compounds affect the growth, invasiveness and metastatic behavior of cancer cells at the molecular level.

Cellular Biochemistry

The modulation of cellular activities by polyphenols, lipids, and fatty acids that lead to beneficial effects on the cardiovascular system and preventive effects on cancer.


Fundamental aspects of hypothermia and cold adaptation as they relate to therapeutic hypothermia and the preservation of transplant organs.


The mechanisms that regulate the growth, immune, and inflammatory signaling relevant to multiple sclerosis, cancer stem cells, inflammation and autoimmune diseases of the brain.

Signal Transduction

Studies on the signaling pathways that regulate growth, survival and invasion of malignant gliomas with the goal of identifying novel targets to improve patient treatment and survival.


Biological markers in human heart transplantation and the development and validation of further risk-prediction models based on markers of inflammation.