Cellular Biochemistry

The Cellular Biochemistry Laboratory has closed.

Rafat Siddiqui, PhD

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Recent Publications

  1. Harvey KA, Xu Z, Saaddatzadeh MR, Wang H, Pollok K, Cohen-Gadol AA, Siddiqui RA. Enhanced anticancer properties of lomustine in conjunction with docosahexaenoic acid in glioblastoma cell lines. J Neurosurg. Mar 2015;122(3):547-556. Link
  2. Xu Z, Harvey KA, Pavlina TM, Zaloga GP, Siddiqui RA. Tocopherol and tocotrienol homologs in parenteral lipid emulsions. Eur J Lipid Sci Technol. Jan 2015;117(1):15-22. Link
  3. Xu Z, Harvey KA, Pavlina TM, Zaloga GP, Siddiqui RA. Distribution of Tocopherols and Tocotrienols in Guinea Pig Tissues Following Parenteral Lipid Emulsion Infusion. JPEN J Parenter Enteral Nutr. Aug 28 2014. Link
  4. Siddiqui RA, Harvey KA, Xu Z, Natarajan SK, Davisson VJ. Characterization of lovastatin-docosahexaenoate anticancer properties against breast cancer cells. Bioorg Med Chem. 2014;22(6): 1899-908. Link
  5. Siddiqui RA, Harvey K. Omega-3 polyunsaturated fatty acids for treatment of nonalcoholic fatty liver disease: a possible case for personalized therapy. J Glycomics Lipidomics. 2014, 4:1. Link
  6. Harvey K, Xu Z, Walker C, Pavlina T, McGrath S, Zaloga G, Siddiqui RA. Parenteral lipid emulsions in guinea pigs differentially influence plasma and tissue levels of fatty acids, squalene, cholesterol, and phytosterols. Lipids. 2014. Link
  7. Siddiqui RA, Harvey KA. Dietary interventions with n-3 fatty acids or probiotics targeting post-myocardial infarction depression. Br J Nutr. 2013;109(1):1-3 Link
  8. Siddiqui RA, Harvey K, Bammerlin E, Ikhlaque N. Docosahexaenoic acid: A potential modulator of brain tumors and metastasis. J Biomol Res Ther. 2013;2(3): 1000e119. Link
  9. Siddiqui RA. Targeting lung inflammation in cystic fibrosis. 2013. J Mol Genet Med 7: 2 (Editorial). Link
  10. Siddiqui RA, Harvey KA, Walker C, Altenburg J, Xu Z, Terry C, Camarillo I, Jones-Hall Y, Mariash C. Characterization of synergistic anti-cancer effects of docosahexaenoic acid and curcumin on DMBA-induced mammary tumorigenesis in mice. BMC cancer. 2013;13:418. Link
  11. Siddiqui RA, Harvey KA. Dietary interventions with n-3 fatty acids or probiotics targeting post-myocardial infarction depression. Br J Nutr. 2013;109(1):1-3. Link
  12. Xu Z, Harvey KA, Pavlina T, Dutot G, Hise M, Zaloga GP, Siddiqui RA. Steroidal compounds in commercial parenteral lipid emulsions. Nutrients. Aug 2012;4(8):904-921. Link
  13. Harvey KA, Walker CL, Xu Z, Whitley P, Siddiqui RA. Trans fatty acids: induction of a pro-inflammatory phenotype in endothelial cells. Lipids. Jul 2012;47(7):647-657. Link
  14. Vanhorn J, Altenburg JD, Harvey KA, Xu Z, Kovacs RJ, Siddiqui RA. Attenuation of niacin-induced prostaglandin D(2) generation by omega-3 fatty acids in THP-1 macrophages and Langerhans dendritic cells. J Inflamm Res. 2012;5:37-50. Link

Abbreviated Biography

Dr. Siddiqui earned his BSc and MSc degrees in Biochemistry from the University of Karachi, in Karachi, Pakistan. He was accepted as a candidate for PhD studies by the University of Oxford (UK), the University of Calgary (Canada), and the University of North Carolina (USA) but decided to accept a prestigious scholarship from the Australian National University in Canberra, Australia. While obtaining his PhD in Australia, he investigated the metabolic basis of cancer cachexia under the supervision of Professor John F. Williams, who is famous for his research on the pentose phosphate pathway. Dr. Siddiqui served as a postdoctoral fellow at Massey University in Palmerton North, New Zealand in the laboratory of Dr. Stuart McCutcheon (currently Vice Chancellor of Auckland University in New Zealand).

Dr. Siddiqui immigrated to America in 1989 at the invitation of Dr. John Exton and a Howard Hughes fellowship at Vanderbilt University Medical Center in Nashville. Dr. Siddiqui began his work as a researcher at Methodist Hospital in 1993 in the Bone Marrow Transplant Research Laboratory. He established his independent research laboratory in 1999 and was the Senior Investigator and Director of the Cellular Biochemistry Research Laboratory at the Methodist Research Institute. Dr. Siddiqui also held adjunct appointments in the Department of Biology, Indiana University-Purdue University and the Department of Medicine, Indiana University Medical School, Indianapolis.

Dr. Siddiqui's research interests are in the area of cancer, inflammation, and cardiovascular diseases. His research emphasis is on modulation of diseases by dietary fatty acids such as omega-3, omega-6, omega-9, and trans fatty acids. Dr. Siddiqui has received funding from the National Cancer Center (NIH), American Heart Association, Showalter Foundation, Abbott Pharmaceuticals, and Baxter Nutrition.

Dr. Siddiqui's Curriculum Vitae