Signal Transduction

Maria Teresa Rizzo, MD

Associate Investigator
Methodist Research Institute
Indiana University Health
1800 N. Capitol Avenue
Indianapolis, IN 46202
P: 317.962.6891
F: 317.962.9369
Laboratory: 317.962.5370

Recent Publications


The Signal Transduction Laboratory studies the signaling pathways that regulate growth, survival, and invasion of malignant gliomas, with the goal of identifying novel targets to improve patient treatment and survival. Specifically, at this time the lab is primarily interested in elucidating the signaling pathways by which arachidonic acid and its metabolites that are generated via the cyclo-oxygenase-2 (COX-2) pathway regulate normal and neoplastic cell growth.

Recent Publications

  1. Davidson J, Rotondo D, Rizzo MT, Leaver HA. Therapeutic Implications of Disorders of Cell Death Signalling: Membranes, Microenvironment and Eicosanoid and Docosanoid Metabolism. Br J Pharmacol. Feb 24 2012. Link
  2. Rizzo MT Cyclooxygenase-2 in oncogenesis. Clin Chim Acta. Apr 11 2011;412(9-10):671-687. Link
  3. Rizzo MT, Leaver HA. Brain endothelial cell death: modes, signaling pathways, and relevance to neural development, homeostasis, and disease. Mol Neurobiol. Aug 2010;42(1):52-63. Link
  4. Leaver HA, Rizzo MT, Whittle IR. Glioma cell death: cell-cell interactions and signalling networks. Mol Neurobiol. Aug 2010;42(1):89-96. Link
  5. Bidwell P, Joh K, Leaver HA, Rizzo MT. Prostaglandin E2 activates cAMP response element-binding protein in glioma cells via a signaling pathway involving PKA-dependent inhibition of ERK. Prostaglandins Other Lipid Mediat. Feb 2010;91(1-2):18-29. Link