Rhabdomyosarcoma is a type of cancer, specifically of connective tissues, in which the cancer cells are thought to arise from skeletal muscle progenitors. It can also be found attached to muscle tissue, wrapped around intestines, or in any anatomic location.

Most occur in areas naturally lacking in skeletal muscle, such as the head, neck, and genitourinary tract. Its two most common forms are embryonal rhabdomyosarcoma and alveolar rhabdomyosarcoma.In the former, which is more common in younger children, the cancer cells resemble those of a typical 6-to-8-week embryo. In the latter, which is more common in older children and teenagers, they resemble those of a typical 10-to-12-week embryo.

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